Synthesis and structure of (2S,4S)-2-alkyl(aryl)-3-(3-sulfanylpropanoyl)-6-oxohexahydropyrimidine-4-carboxylic acids |
| |
Authors: | A Yu Ershov D G Nasledov E V Parilova I V Lagoda V V Shamanin |
| |
Institution: | 1. Institute of Macromolecular Compounds, Russian Academy of Sciences, Bolshoi pr. V.O. 31, St. Petersburg, 199004, Russia 2. Research Test Center (of Medico-Biological Protection) of the State Research Test Institute of Military Medicine, Defense Ministry of the Russian Federation, St. Petersburg, Russia
|
| |
Abstract: | Proceeding from natural amino acid L-asparagine and commercially available aldehydes a stereoselective synthesis was developed of (2S,4S)-2-alkyl(aryl)-3-(3-sulfanylpropanoyl)-6-oxohydropyrimidine-4-carboxylic acids, potential antihypertensive drugs, inhibitors of the angiotensin converting enzyme. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|