Synthesis and antiviral activity of adamantyl-containing phosphonous and phosphinic acids |
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| Authors: | A N Reznikov Yu N Klimochkin O V Savinova S V Orlova N L Bogdanova E I Boreko |
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| Institution: | 1. Samara State Technical University, ul. Molodogvardeiskaya 244, Samara, 443100, Russia
2. Republican Research and Practical Center for Epidemiology and Microbiology, Ministry of Health of the Republic of Belarus, Minsk, Belarus
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| Abstract: | The method of adamantly-containing phosphonous and phosphinic acids preparation, based on radical addition of hypophosphorous acid and sodium hypophosphite to unsaturated derivatives of adamantane, has been developed. Unsymmetrical phosphinic acids have been prepared by reacting bistrimetylsilyl esters of phosphonous acids with halides. The obtained phosphinic acids exhibit antiviral activity against herpes simplex virus, influenza A (H5N1), respiratory syncytial virus, and adenovirus. |
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