| 一个简单、环境友好的硅胶固载硫酸催化Biginelli反应体系(英文) |
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| 作者姓名： | Mahmood TAJBAKHSH Yousef RANJBAR Abdolhosein MASUODI Samad KHAKSAR |
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| 作者单位： | Chemistry Department,University of Mazandaran;Chemistry Department,Payame Noor University;Chemistry Department,Islamic Azad University |
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| 基金项目： | supported by the Research Council of Payame Noor University |
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| 摘 要： | A protocol for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones and-thiones was developed by means of a three-component condensation of an aldehyde,a β-dicarbonyl compound,and urea or thiourea in acetic acid catalyzed by silica-bonded S-sulfonic acid.Compared to the classical Biginelli reaction conditions,this new protocol has the advantages of consistently excellent yields and short reaction times.After the reaction,the catalyst could be recovered easily and reused with little change in its activity.
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| 关 键 词： | Biginelli reaction silica-bonded S-sulfonic acid dihydropyrimidinone |
A Simple and Environmentally Benign Protocol for Biginelli Reactions Catalyzed by Silica-Bonded S-Sulfonic Acid |
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| Mahmood TAJBAKHSH,Yousef RANJBAR,Abdolhosein MASUODI,Samad KHAKSAR.A Simple and Environmentally Benign Protocol for Biginelli Reactions Catalyzed by Silica-Bonded S-Sulfonic Acid[J].Chinese Journal of Catalysis,2012(9):1542-1545. |
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| Authors: | Mahmood TAJBAKHSH Yousef RANJBAR Abdolhosein MASUODI Samad KHAKSAR |
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| Institution: | Mahmood TAJBAKHSH 1,,Yousef RANJBAR 2,Abdolhosein MASUODI 2,Samad KHAKSAR 3 1 Chemistry Department,University of Mazandaran,PO Box 453,Babolsar,Iran 2 Chemistry Department,Payame Noor University,PO Box 4697,Tehran,Iran 3 Chemistry Department,Islamic Azad University,Ayatollah Amoli Branch,PO Box 678,Amol,Iran |
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| Abstract: | A protocol for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones and-thiones was developed by means of a three-component condensation of an aldehyde,a β-dicarbonyl compound,and urea or thiourea in acetic acid catalyzed by silica-bonded S-sulfonic acid.Compared to the classical Biginelli reaction conditions,this new protocol has the advantages of consistently excellent yields and short reaction times.After the reaction,the catalyst could be recovered easily and reused with little change in its activity. |
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| Keywords: | Biginelli reaction silica-bonded S-sulfonic acid dihydropyrimidinone |
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