The enzymology of clavam and carbapenem biosynthesis |
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| Authors: | Kershaw Nadia J Caines Matthew E C Sleeman Mark C Schofield Christopher J |
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| Institution: | Department of Chemistry and Oxford Centre for Molecular Sciences, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK. |
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| Abstract: | The enzyme-catalysed reactions involved in formation of the bicyclic clavam and carbapenem nuclei, including beta-amino acid and beta-lactam formation, are discussed and compared with those involved in penicillin and cephalosporin biosynthesis. The common role of unusual oxidation reactions in the biosynthetic pathways and the lack of synthetic reagents available to effect them are highlighted. |
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