Reactions with pyrrolidine-2,4-diones,II: New approaches to the synthesis of substituted 5,6-dihydropyrrolo[3,4-d][1,2,3]triazol-4(2H,4H)ones |
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Authors: | Mohamed G Kassem S A Shams El-Dine Farid S G Soliman Manal N S Saudi |
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Institution: | (1) Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, A. R. Egypt |
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Abstract: | Summary Approaches leading to 5,6-dihydro-5,6-diphenyl-2-substituted-pyrrolo3,4-d]1,2,3]-triazol-4(2H,4H)-ones (10) are described. The first approach consists of cyclodehydrating 3(or 4)-hydroxyimino-1,5-diphenyl-4(or 3)-(4-substituted phenylhydrazono)pyrrolidin-2-ones (4,7) with boiling acetic anhydride. The second approach involves cyclization of 3(or 4)-acetoxyimino-1,5-diphenyl-4(or 3)-(4-substituted phenylhydrazono)pyrrolidin-2-ones (8,9) with elimination of acetic acid upon treatment with sodium hydroxide.Part of the work has been presented at the 8th International Congress of Heterocyclic Chemistry (August 1981), Graz, Austria |
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Keywords: | 3(or 4)-Hydroxyimino-1 5-diphenyl-4(or 3)-(4-substituted phenylhydrazono)pyrrolidin-2-ones 3(or 4)-Acetoxyimino-1 5-diphenyl-4(or 3)-(4-substituted phenylhydrazono)pyrrolidin-2-ones 5 6-Dihydro-5 6-diphenyl-2-substituted-pyrrolo[3 4-d][1 2 3]triazol-4(2H 4H)-ones |
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