Biodistribution of the bone imaging agents99mTc-DHPE and99mTc-MDP in rats |
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Authors: | S. C. Archimandritis Al. K. Tsolis |
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Affiliation: | (1) Aghia Paraskevi Attikis, N.R.C. Demokritos Division of Radiodiagnostic Products and Radioisotopes, 15310 Athens, Greece;(2) Department of Chemistry, University of Patras, Patras, Greece |
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Abstract: | The self life of the freeze-dried formulation kits utilized for the preparation of the new bone imaging radiopharmaceutical99mTc-1,2-dihydroxy-1,2-bis/dihydroxyphosphinyl/ethane /99mTc-DHPE/ has been investigated as well as the toxicity of the DHPE. In a biodistribution investigation of99mTc-DHPE in rats, in comparison to99mTc-methylenediphosphanate /99mTc-MDP/,99mTc-DHPE exhibited a certain extent higher skeleton uptake, a higher blood clearance rate, a very low concentration in other organs, a satisfactory biological stability and excretion primarily through the kidneys. These properties demonstrate that99mTc-DHPE is a new promising skeleton imaging radio-pharmaceutical. |
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