Absolute configuration of scyphostatin |
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| Authors: | Saito Tanaka Fujimoto Kogen |
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| Institution: | Exploratory Chemistry Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan. |
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| Abstract: | reaction: see text] The absolute configuration of the side chain of scyphostatin (1) has been established. The chemical degradation of 1 gave 4 and 9, which correspond to the C7'-C12' and C13'-C16' fragments of the natural products, respectively. The spectroscopic data and alpha]D values of both compounds were compared to those of authentic samples. The results show that the absolute configuration of 1 is 8'R,10'S,14'R. |
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