A novel and efficient synthesis of 3-fluorooxindoles from indoles mediated by Selectfluor |
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Authors: | Takeuchi Y Tarui T Shibata N |
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Affiliation: | Faculty of Pharmaceutical Sciences, Toyama Medical & Pharmaceutical University, Japan. takeuchi@ms.toyama-mpu.ac.jp |
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Abstract: | [reaction: see text] Treatment of several 3-substituted indoles, including derivatives of tryptophan and serotonin, with commercially available Selectfluor in acetonitrile/water furnished 3-substituted 3-fluorooxindoles in good to high yields. Since 3-fluorooxindoles obtained are sterically similar to both oxindoles and 3-hydroxyoxindoles, they should be useful as probes for investigating the enzymatic mechanism of indole biosynthesis and metabolism. |
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