Lactone synthesis based on atom transfer carbonylation |
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Authors: | Kreimerman Ryu Minakata Komatsu |
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Institution: | Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita, Japan. |
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Abstract: | reaction: see text] Five- to seven-membered lactones were prepared from omega-hydroxyalkyl iodides and CO by atom transfer carbonylation without the need for transition metal catalysts. The reaction proceeds via a hybrid radical/ionic mechanism in which the intramolecular alcoholysis of an omega-hydroxyacyl iodide, arising from atom transfer carbonylation, leads to the lactone. |
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