Total synthesis of (-)-reveromycin B |
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| Authors: | Cuzzupe A N Hutton C A Lilly M J Mann R K Rizzacasa M A Zammit S C |
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| Institution: | School of Chemistry, The University of Melbourne, Parkville, Victoria, Australia. |
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| Abstract: | structure: see text] The total synthesis of the epidermal growth factor inhibitor reveromycin B (2) is described. A novel, convergent, and stereoselective reaction sequence was utilized to construct the 5,6-spiroketal system 10 which was converted into the natural product 2 by a 16-step sequence. |
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