A new synthesis of p-hydroxy phenylglycine and some analogues from p-benzoquinone |
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Authors: | Titulaer Zhu Klunder Zwanenburg |
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Institution: | Department of Organic Chemistry, NSR Institute for Molecular Structure, Design and Synthesis, University of Nijmegen, Toernooiveld, The Netherlands. |
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Abstract: | reaction: see text] A new route to p-hydroxy phenylglycine and N-substituted analogues has been developed starting from p-benzoquinone. 1,2-Addition of methyl lithioacetate to p-benzoquinone and subsequent quenching of the oxygen anion with methyl chloroformate, followed by an elimination-addition reaction with an appropriate amine, resulted in the desired amino acid derivatives. A diastereoselectivity of 60% was achieved using 8-phenylmenthyl acetate as the chiral auxiliary. |
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