Enantioselective synthesis of the [6,6] spiroketal core of reveromycin A |
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Authors: | Drouet K E Ling T Tran H V Theodorakis E A |
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Institution: | Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla 92093-0358, USA. |
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Abstract: | structure: see text] Reveromycin A (1) belongs to a family of microbial polyketides with unusual structural features and biological activities. The structure of 1 is composed of a 6,6] spiroketal core decorated with highly unsaturated side chains. As a prelude to the synthesis of 1, we present herein a short, efficient, and enantioselective synthesis of the C9-C21 fragment 5 (spiroketal core) of reveromycin A. |
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