Synthesis of the C1-C13 fragment of leucascandrolide A |
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Authors: | Crimmins M T Carroll C A King B W |
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Affiliation: | Venable and Kenan Laboratories of Chemistry, The University of North Carolina at Chapel Hill, 27599-3290, USA. crimmins@email.unc.edu |
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Abstract: | [reaction: see text] The synthesis of the C1-C13 fragment 3 of leucascandrolide A has been completed utilizing a stereoselective and regioselective reductive cleavage of a highly functionalized spiroketal to incorporate the cis-2,6-disubstituted tetrahydropyan. The spiroketal was constructed by addition of a lithiated pyrone 5 to aldehyde 6. |
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