New diffusion-edited NMR experiments to expedite the dereplication of known compounds from natural product mixtures |
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Authors: | Williamson R T Chapin E L Carr A W Gilbert J R Graupner P R Lewer P McKamey P Carney J R Gerwick W H |
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Institution: | College of Pharmacy, Oregon State University, Corvallis 97331, USA. |
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Abstract: | reaction: see text] We present two new diffusion-edited NMR experiments, improved DECODES and HETDECODES, that sort the constituents in a mixture by their individual diffusion coefficients. These experiments should allow the partial NMR spectral assignment and cursory structure elucidation of compounds in a complex mixture as an aid in the dereplication of known or nuisance compounds. |
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