Water-soluble magnetic nanoparticles with biologically active stabilizers |
| |
Authors: | Alla Zablotskaya Izolda Segal Mikhail Maiorov Elmars Blums Ilona Domracheva |
| |
Affiliation: | a Latvian Institute of Organic Synthesis, 21 Aizkraukles Street, Riga LV-1006, Latvia b Institute of Physics, University of Latvia, 32 Miera, Salaspils LV-2169, Latvia |
| |
Abstract: | We present the results of the interaction of iron oxide nanoparticles with some biologically active surfactants, namely, oleic acid and cytotoxic alkanolamine derivatives. Physico-chemical properties, as magnetization, magnetite concentration and particle diameter, of the prepared magnetic samples were studied. The nanoparticle size of 11 nm for toluene magnetic fluid determined by TEM is in good agreement with the data obtained by the method of magnetogranulometry. In vitro cytotoxic effect of water-soluble nanoparticles with different iron oxide:oleic acid molar ratio were revealed against human fibrosarcoma and mouse hepatoma cells. In vivo results using a sarcoma mouse model showed observable antitumor action. |
| |
Keywords: | Magnetic nanoparticle Iron oxide Oleic acid Antitumor activity Cytotoxicity |
本文献已被 ScienceDirect 等数据库收录! |
|