High content analysis of the biocompatibility of nickel nanowires |
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Authors: | Fiona Byrne,Adriele Prina-Mello,Bashir M. Mohamed,Yurii K. Gun&rsquo ko,Yuri Volkov |
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Affiliation: | a CRANN and School of Physics, Trinity College, Dublin 2, Ireland b Department of Clinical Medicine, Trinity College Health Sciences Centre, Dublin 8, Ireland c CRANN and School of Chemistry, Trinity College, Dublin 2, Ireland |
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Abstract: | Nickel nanowires, 20 μm long and 200 nm in diameter, were fabricated by electrodeposition into alumina templates, and characterised by superconducting quantum interference device (SQUID) magnetometer, X-ray diffraction and scanning electron microscopy. Biocompatibility studies of nickel nanowires with differentiated THP-1 cell line-derived macrophages were carried out. From a multiparametric assay, using high content analysis (HCA), the critical time points and concentrations of nickel nanowires on THP-1 cellular response were identified. The nanowires displayed little or no toxic effects on THP-1 cells over short incubation times (10 h), and at low concentrations (<100 nanowires per cell). Our findings indicate the potential suitability of these wires for biological and clinical applications. |
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Keywords: | Magnetic nanowire Nickel Electrodeposition Cytotoxicity Biocompatibility High content analysis |
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