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Preparation of spherical and uniform-sized ferrite nanoparticles with diameters between 50 and 150 nm for biomedical applications |
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| Authors: | Toshiyuki Tanaka Ryuichi Shimazu Masaru Tada Adarsh Sandhu Hiroshi Handa Masanori Abe |
| Institution: | a Department of Physical Electronics, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8552, Japan b Tokyo Bio R & D Center, Motortronics Laboratory, Tamagawa Seiki Co., Ltd., 4259-3 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa 226-8510, Japan c Quantum Nanoelectronics Research Center, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8552, Japan d Integrated Research Institute, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8552, Japan e Department of Biological Information, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa 226-8501, Japan |
| Abstract: | Spherical uniform-sized iron ferrite nanoparticles were synthesized by adding a disaccharide and seed ferrite crystals into an aqueous reaction solution. The average size range 50-150 nm was controlled by choosing one out of five disaccharides and by changing the amount of the seed crystals. The particles had a saturation magnetization and a crystalline structure which are similar to those of intermediate Fe3O4-γ-Fe2O3. When coated with citrate, the particles with nearly 100 nm diameter were stably suspended in water for 2 days. These novel particles will be utilized as magnetic carriers in biomedical applications. |
| Keywords: | Ferrite nanoparticle Fe3O4 γ-Fe2O3 Spherical shape Uniform size Biomedical application |
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