Complementary detection of prostate-specific antigen using In2O3 nanowires and carbon nanotubes |
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| Authors: | Li Chao Curreli Marco Lin Henry Lei Bo Ishikawa F N Datar Ram Cote Richard J Thompson Mark E Zhou Chongwu |
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| Institution: | Department of Electrical Engineering, University of Southern California, Los Angeles, California 90089, USA. |
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| Abstract: | We report complementary detection of prostate-specific antigen (PSA) using n-type In2O3 nanowires and p-type carbon nanotubes. Our innovation involves developing an approach to covalently attach antibodies to In2O3 NW surfaces via the onsite surface synthesis of phosphonic acid-succinylimide ester. Electronic measurements under dry conditions revealed complementary response for In2O3 NW and SWNT devices after the binding of PSA. Real-time detection in solution has also been demonstrated for PSA down to 5 ng/mL, a benchmark concentration significant for clinical diagnosis of prostate cancer, which is the most frequently diagnosed cancer. |
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