Structure and cytotoxicity of phidianidines A and B: first finding of 1,2,4-oxadiazole system in a marine natural product |
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| Authors: | Carbone Marianna Li Yan Irace Carlo Mollo Ernesto Castelluccio Francesco Di Pascale Antonio Cimino Guido Santamaria Rita Guo Yue-Wei Gavagnin Margherita |
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| Affiliation: | Consiglio Nazionale delle Ricerche (CNR), Istituto di Chimica Biomolecolare (ICB), Pozzuoli (Na), Italy. |
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| Abstract: | Two indole alkaloids, phidianidines A (1) and B (2), exhibiting an uncommon 1,2,4-oxadiazole ring linked to the indole system, have been isolated from the marine opisthobranch mollusk Phidiana militaris. The structures of the two metabolites have been elucidated by spectroscopic techniques. Phidianidines exhibit high cytotoxicity against tumor and nontumor mammalian cell lines in in vitro assays. |
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