Highly enantioselective direct aldol reaction catalyzed by cinchona derived primary amines |
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| Authors: | Zheng Bao-Lei Liu Quan-Zhong Guo Chuan-Sheng Wang Xue-Lian He Long |
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| Institution: | College of Chemistry and Chemical Engineering, China West Normal University, Nanchong, 637002, China. |
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| Abstract: | Highly enantioselective aldol reactions of aldehydes with cyclic ketones catalyzed by a primary amine derived from cinchonine are reported. Aromatic aldehydes reacted with various cyclic ketones cleanly to afford the anti-aldol adducts in up to 99% yield, with good diastereoselectivities (up to 9 : 1) and excellent enantioselectivities (up to 99% ee). |
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