Molecular imprinting polymer electrosensor based on gold nanoparticles for theophylline recognition and determination期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Molecular imprinting polymer electrosensor based on gold nanoparticles for theophylline recognition and determination

Authors:

Xianwen Kan Tingting Liu Hong Zhou Chen Li Bin Fang

Institution:

1. College of Chemistry and Materials Science, Anhui Key Laboratory of Chemo-Biosensing, Anhui Normal University, Wuhu, 241000, People’s Republic of China

Abstract:

An electrochemical sensor for theophylline (ThPh) was prepared by electropolymerizing o-phenylenediamine on a glassy carbon electrode in the presence of ThPh via cyclic voltammetry, followed by deposition of gold nanoparticles using a potentiostatic method. The effects of pH, ratio between template molecule and monomer, number of cycles for electropolymerization, and of the solution for extraction were optimized. The current of the electro-active model system hexacyanoferrate(III) and hexacyanoferrate(IV) decreased linearly with successive addition of ThPh in the concentration range between 4.0?×?10^?7?~?1.5?×?10^?5 mol·L^?1 and 2.4?×?10^?4?~?3.4?×?10^?3 mol·L^?1, with a detection limit of 1.0?×?10^?7 mol·L^?1. The sensor has an excellent recognition capability for ThPh compared to structurally related molecules, can be regenerated and is stable.

Figure
In this paper, an electrochemical sensor for theophylline (ThPh) was prepared by electropolymerizing o-phenylenediamine (o-PD) on a glassy carbon electrode in the presence of ThPh via cyclic voltammetry, followed by deposition of gold nanoparticles to enhance the sensitivity of the sensor. Therefore, the sensor showed a high sensitivity for ThPh determining. Peak current of Fe(CN)₆]^3?/Fe(CN)₆]^4? varied linearly with the concentration of ThPh in the range of 4.0×10^-7~1.5×10^-5 mol·L^-1 and 2.4×10^-4~3.4×10^-3 mol·L^-1, and the detection limit reached 1.0×10^-7 mol·L^-1. Compared to structurally related molecules, the sensor also has a high recognition capability for ThPh. With excellent regeneration property and stability, the present sensor maybe provides a new class of polymer modified electrodes for sensor applications.

Keywords:

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