Kinetics and mechanism of reactions of photoexcited kynurenine with molecules of some natural compounds |
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Authors: | O. A. Snytnikova P. S. Sherin L. V. Kopylova Yu. P. Tsentalovich |
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Affiliation: | (1) International Tomography Center, Siberian Branch of the Russian Academy of Sciences, 3a Institutskaya ul., 630090 Novosibirsk, Russian Federation;(2) Novosibirsk State University, 2 ul. Pirogova, 630090 Novosibirsk, Russian Federation |
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Abstract: | Photochemical reactions involving kynurenines, viz., molecules present in the eye lens, can result in modifications of the lens proteins and cause a development of a cataract. The rate constants of the reactions of photoexcited kynurenine with several amino acids and antioxidants contained in the lens were measured. The most efficient quenchers of triplet kynurenine are amino acids tryptophan and tyrosine, as well as antioxidant ascorbate. In all cases, the quenching reaction proceeds by the electron transfer mechanism, except for the reaction with oxygen where transfer of the triplet energy to the oxygen molecule occurs. Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 4, pp. 704–710, April, 2007. |
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Keywords: | kynurenine laser flash photolysis triplet excited kynurenine antioxidants amino acids electron transfer |
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