Oxidation chemistry and biochemistry of some biologically important purines and indoleamines |
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| Institution: | 1. State-Key Laboratory and Research Institute of Elemento-Organic Chemistry, National Pesticide Engineering Research Center, College of Chemistry, Nankai University, Tianjin 300071, China;2. Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China;3. Patent Examination Cooperation Jiangsu Center of the Patent Office, SIPO, Suzhou 215163, China;1. Bundesanstalt für Materialforschung und -prüfung (BAM), Unter den Eichen 87, 12205 Berlin, Germany;2. Fakultät für Mathematik und Naturwissenschaften - Physik der kondensierten Materie, Bergische Universität Wuppertal, Gauss-strasse 20, 42097 Wuppertal, Germany;1. Department of Materials Engineering, Indian Institute of Science, Bangalore, Karnataka, 560012, India;2. Centre for BioSystems Science and Engineering, Indian Institute of Science, Bangalore, Karnataka, 560012, India;1. Beijing Key Laboratory of Functional Food from Plant Resources, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China;2. Japan International Research Center for Agricultural Sciences, Tsukuba 305-8686, Japan;3. Jiangsu Hengshun Vinegar Industry Co., Ltd., Zhenjiang 214043, China;1. Department of Applied Chemistry, Cochin University of Science and Technology, Kochi, 22, Kerala, India;2. Agroprocessing & Natural Products Division, National Institute for Interdisciplinary Science & Technology (CSIR-NIIST), Thiruvananthapuram, 695019, India |
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| Abstract: | The electrochemical oxidation of 7-methyluric acid and 5,6-dihydroxytryptamine (5,6-DHT) in aqueous solutions has been studied. The oxidation products have been separated and characterized using melting point, mass, 1H nuclear magnetic resonance and spectral studies, and tentative mechanisms for the oxidation have been suggested. One of the oxidation products of 5,6-DHT, i.e. 2,7′-bi(5,6-DHT), has been found to produce a substantial neurotoxic effect in mice brain. |
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