A simple and practical access to enantiopure 2,3-diamino acid derivatives |
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| Institution: | 1. Institutes of Biomedical Sciences, Fudan University, 130 Dongan Road, Shanghai 200032, China;2. Department of Natural Products Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China;1. Centro de Estudio de Compuestos Orgánicos, CEDECOR (CIC – UNLP), Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 47 y 115, 1900 La Plata, Argentina;2. LANADI e IFLP (CCT-La Plata), Departamento de Física, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, CC 67, 1900 La Plata, Argentina;3. Centro de Investigación y Desarrollo en Ciencias Aplicadas “Dr. Jorge J. Ronco”, CINDECA (CONICET-CCT- La Plata-UNLP), Universidad Nacional de La Plata, Facultad de Ciencias Exactas, calle 47 n° 257, 1900 La Plata, Argentina;1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kuwait University, P.O. Box 24923, Safat 13110, Kuwait;2. Department of Pharmaceutical Sciences, College of Pharmacy, Rosalind Franklin University of Medicine & Science, North Chicago 60064, USA;3. Department of Microbiology, Faculty of Medicine, Kuwait University, P.O. Box 24923, Safat 13110, Kuwait;4. Department of Biochemistry, Faculty of Medicine, Kuwait University, P.O. Box 24923, Safat 13110, Kuwait;1. School of Physical Sciences, Jawaharlal Nehru University, New Delhi 110 067, India;2. Department of Chemistry, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh 495 009, India |
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| Abstract: | Enantiomerically pure (4R,5R)- and (4S,5S)-2-imidazolines 5 were conveniently obtained on a gram scale. These can be converted into enantiopure (2R,3R)-2,3-diamino ester 6 or 2,3-diamino alcohol 7 by hydrolysis or reduction. |
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