Asymmetric reduction of N-methylglyoxyloyl- and N-phenylglyoxyloyl-(2R)-bornane-10,2-sultam |
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| Institution: | 1. Department of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland;2. Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland;1. Department of Chemical Engineering, Indian Institute of Technology Guwahati, Guwahati 781039, Assam, India;2. Department of Chemical Engineering, Maulana Azad National Institute of Technology Bhopal, Bhopal 462003, Madhya Pradesh, India;1. Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Ministry of Education, Nanjing, 210009, China;2. Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, 210009, China;3. Hangzhou Institute of Pharmaceutical Innovation, China Pharmaceutical University, 291 Fucheng Lu, Hangzhou, 310018, China;4. School of Pharmacy, Air Force Medical University, Xi''an, 710032, China;1. Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 2238522, Japan;2. Department of Biochemistry, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan |
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| Abstract: | N-Methylglyoxyloyl- (1a) and N-phenylglyoxyloyl-(2R)-bornane-10,2-sultam (1b), when reduced under various conditions, afford mixtures of two diastereoisomeric alcohols. In both cases, the reaction conditions lead to excess of both (S) and (R) configuration at the newly created stereogenic center of diastereomeric products have been found. |
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