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Protecting group controlled stereoselective alkylation of asymmetrized bis(hydroxymethyl)propanoates (BHYMP*) |
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| Affiliation: | 1. State Key Laboratory of Natural Medicines and Department of Pharmacology, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, PR China;2. Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, PR China;4. College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315800, PR China |
| Abstract: | The diastereoselective methylation of the enolates derived from some asymmetrized bis(hydroxymethyl)propanoates (BHYMP*) has been studied. Good results were achieved when one of the two hydroxymethyl groups was unprotected. The induction was interpreted on the basis of an acyclic stereocontrol governed by stereoelectronic effects. |
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