A new C2-symmetric chiral diphosphine ligand: palladium-catalyzed enantioselective allylic alkylation of cycloalkenyl substrate |
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| Institution: | 1. Laboratory of Biological Chemistry, University of Ioannina Medical School, Ioannina, Greece;2. Department of Anatomy-Histology-Embryology, University of Ioannina Medical School, Ioannina, Greece;3. Lady Davis Institute for Medical Research and Department of Medicine, McGill University, Montreal, Canada |
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| Abstract: | A novel C2-symmetric chiral diphosphine ligand 1 was developed using (2S)-2-amino-1-(diphenylphosphino)-3-methylbutane 2 which was derived from l-valine as in the previous work for the chiral amidine ligand, VALAP. Ligand 1 demonstrated extremely high levels of asymmetric induction, over 99% ee in palladium-catalyzed allylic alkylations of 2-cyclohexen-1-yl pivalate 5. |
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