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Post-translational His-Cys cross-linkage formation in tyrosinase induced by copper(II)-peroxo species |
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| Authors: | Fujieda Nobutaka Ikeda Takuya Murata Michiaki Yanagisawa Sachiko Aono Shigetoshi Ohkubo Kei Nagao Satoshi Ogura Takashi Hirota Shun Fukuzumi Shunichi Nakamura Yukihiro Hata Yoji Itoh Shinobu |
| Institution: | Department of Material and Life Science, Graduate School of Engineering, Osaka University, 2-1 Yamada-oka, Suita, Osaka 565-0871, Japan. |
| Abstract: | Autocatalytic formation of His-Cys cross-linkage in the enzyme active site of tyrosinase from Aspergillus oryzae has been demonstrated to proceed by the treatment of apoenzyme with Cu(II) under aerobic conditions, where a (μ-η(2):η(2)-peroxo)dicopper(II) species has been suggested to be involved as a key reactive intermediate. |
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