A dual-catalysis/anion-binding approach to the kinetic resolution of allylic amines |
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| Authors: | Klauber Eric G Mittal Nisha Shah Tejas K Seidel Daniel |
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| Affiliation: | Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, United States. |
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| Abstract: | A dual-catalysis approach enables the small-molecule catalyzed kinetic resolution of allylic amines by acylation. By employing 2 mol % of each 4-(pyrrolidino)pyridine (PPY) and a readily available chiral hydrogen-bonding cocatalyst, the first nonenzymatic kinetic resolution of allylic amines was accomplished with s factors of up to 20. |
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