Understanding the structural features of JAK2 inhibitors: a combined 3D-QSAR,DFT and molecular dynamics study |
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| Authors: | Babu Sathya Nagarajan Santhosh Kumar Madhavan Thirumurthy |
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| Affiliation: | 1.Computational Biology Lab, Department of Genetic Engineering, School of Bioengineering, SRM Institute of Science and Technology, SRM Nagar, Kattankulathur, Chennai, 603203, India
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| Abstract: | Molecular Diversity - JAK2 plays a critical role in JAK/STAT signaling pathway and in patho-mechanism of myeloproliferative disorders and autoimmune diseases. Thus, effective JAK2 inhibitors... |
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