Biomonitoring of benzene and toluene in human blood by headspace-solid-phase microextraction |
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| Authors: | E Schimming K Levsen C Köhme W Schürmann |
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| Institution: | Fraunhofer-Institut für Toxikologie und Aerosolforschung, Nikolai-Fuchs-Stra?e 1, D-30625 Hannover, Germany, DE
Medizinische Hochschule Hannover, Abteilung für Pneumologie, Carl-Neuberg-Stra?e 1, D-30625 Hannover, Germany, DE
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| Abstract: | A simple and rapid method for the determination of benzene and toluene in whole blood by headspace-solid-phase microextraction (HS-SPME) is described. Using SPME fibres coated with 65 μm carboxene/polydimethylsiloxane, limits of quantification (LOQ) of 5 ng/L for benzene and 25 ng/L for toluene are achieved. As a result of its large linear range (i.e. 5–5000 ng/L for benzene) the method is suitable for biomonitoring of both occupationally and environmentally exposed people. The reproducibility of the determination of benzene is ≤ 8%. An interlaboratory comparison demonstrated that the method proposed here compares favorably with existing methods (dynamic headspace, purge and trap). |
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