| 环糊精在金属酶模拟中的应用 |
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| 引用本文： | 周映华,毛宗万. 环糊精在金属酶模拟中的应用[J]. 中国科学B辑, 2009, 39(4): 289-300 |
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| 作者姓名： | 周映华 毛宗万 |
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| 作者单位： | 中山大学化学与化学工程学院;生物无机与合成化学教育部重点实验室; |
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| 摘 要： | 非共价作用（如氢键、静电和疏水作用）普遍存在于天然金属酶中,对酶活化或底物催化过程有重要的协同作用.近年来基于超分子化学理论的金属酶模拟研究不断向酶的活性中心亚稳态和次层结构的生物功能模拟方向发展.本文将根据报道的文献并结合本课题组的研究工作,对环糊精（一种重要的超分子主体）构建金属酶模型的研究进行综述.
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| 关 键 词： | 金属酶模拟 环糊精 包合物 超分子化学 |
| 收稿时间： | 2008-12-02 |
| 修稿时间： | 2008-12-27 |
Metalloenzyme mimics based on cyclodextrin complexes |
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| ZHOU YingHua,MAO ZongWan MOE Key Laboratory of Bioinorganic , Synthetic Chemistry,School of Chemistry , Chemical Engineering Sun Yat-Sen University,Guangzhou ,China. Metalloenzyme mimics based on cyclodextrin complexes[J]. Science in China(Series B), 2009, 39(4): 289-300 |
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| Authors: | ZHOU YingHua MAO ZongWan MOE Key Laboratory of Bioinorganic Synthetic Chemistry School of Chemistry Chemical Engineering Sun Yat-Sen University Guangzhou China |
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| Affiliation: | ZHOU YingHua,MAO ZongWan* MOE Key Laboratory of Bioinorganic , Synthetic Chemistry,School of Chemistry , Chemical Engineering Sun Yat-Sen University,Guangzhou 510275,China |
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| Abstract: | Non-covalent interactions, such as hydrogen bonding, electrostatic and hydrophobic interactions, univer- sally exist in metalloenzymes, and play an important cooperative role on the enzyme activation or substrate catalytic processes. Recently, the metalloenzyme mimicking based on the supramolecular chemistry is progressing towards the biological functional simulation involving the metastable intermediate and the microenvironment of the active site. In this paper, the research of the metalloenzyme models con... |
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| Keywords: | metalloenzyme mimic cyclodextrin inclusion complex supramolecular chemistry |
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