Pd-catalyzed cycloisomerization-allylation of 4-alkynones: synthesis of 5-homoallylfuran derivatives |
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Authors: | Akio Saito |
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Institution: | Laboratory of Organic Reaction Chemistry, Showa Pharmaceutical University, 3-3165 Higashi-Tamagawagakuen, Machida, Tokyo 194-8543, Japan |
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Abstract: | In the presence of Pd2(dba)3-tBu3P catalyst and Cs2CO3, cycloisomerization-allylation reactions of 4-alkynone derivatives with allyl carbonates in MeCN proceed in 5-exo mode to give highly-substituted furans having homoallyl groups at 5-position. |
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Keywords: | Cascade reaction Cycloisomerization Allylation syn-Oxipalladation Furan Alkynone |
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