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Role of Hydrogen‐Bonding Acceptors in Organo‐Enamine Catalysis |
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| Authors: | Junbin Han Zhichao Lu Andrew L. Flach Prof. Robert S. Paton Prof. Gerald B. Hammond Prof. Bo Xu |
| Affiliation: | 1. Department of Chemistry, University of Louisville, Louisville, Kentucky 40292 (USA);2. Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA (UK);3. College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Lu, Shanghai 201620 (P. R. China) |
| Abstract: | A hydrogen bond acceptor plays an important role in the catalytic cycle of organo‐enamine catalysis. It can effectively influence the rate of reaction through hydrogen bonding interaction with enammonium (N‐protonated enamine intermediate). Our findings are supported by both kinetic experiments and quantum chemical calculations. |
| Keywords: | enamine hydrogen bonding acceptor kinetics organocatalysis |