Palladium‐Catalyzed Oxidative Cycloisomerization of 2‐Cinnamyl‐1,3‐Dicarbonyls: Synthesis of Functionalized 2‐Benzyl Furans |
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| Authors: | Rajender Nallagonda Reddy Rajasekhar Reddy Dr Prasanta Ghorai |
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| Institution: | Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhauri, Indore By‐pass Road, Bhopal‐462066 (India) |
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| Abstract: | A new palladium‐catalyzed intramolecular oxidative cycloisomerization of readily available starting materials, 2‐cinnamyl‐1,3‐dicarbonyls, has been demonstrated for the creation of structurally diverse 2‐benzyl furans. The cycloisomerization occurs by a regioselective 5‐exo‐trig pathway. The reaction shows a broad substrate scope with good to excellent yields. Furthermore, a one‐pot procedure has been executed by using readily available cinnamyl alcohols and 1,3‐diketones. |
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| Keywords: | cycloisomerization furans heterocycles oxidation palladium |
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