Room‐Temperature Decarboxylative Couplings of α‐Oxocarboxylates with Aryl Halides by Merging Photoredox with Palladium Catalysis |
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| Authors: | Wan‐Min Cheng Dr Rui Shang Dr Hai‐Zhu Yu Prof Dr Yao Fu |
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| Institution: | iChEM, CAS Key Laboratory of Urban Pollutant Conversion, Anhui Province Key Laboratory of Biomass Clean Energy, Department of Chemistry, University of Science and Technology of China, Hefei 230026 (P.R. China) |
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| Abstract: | Enabled by merging iridium photoredox catalysis and palladium catalysis, α‐oxocarboxylate salts can be decarboxylatively coupled with aryl halides to generate aromatic ketones and amides at room temperature. DFT calculations suggest that this reaction proceeds through a Pd0–PdII–PdIII pathway, in which the PdIII intermediate is responsible for reoxidizing IrII to complete the IrIII–*IrIII–IrII photoredox cycle. |
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| Keywords: | C C coupling decarboxylation homogeneous catalysis palladium photocatalysis |
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