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A Mild and Regioselective Route to Functionalized Quinazolines |
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| Authors: | Tracy M. M. Maiden Dr. Stephen Swanson Dr. Panayiotis A. Procopiou Prof. Joseph P. A. Harrity |
| Affiliation: | 1. Department of Chemistry, University of Sheffield, Sheffield, S3 7HF (UK);2. GlaxoSmithKline, Stevenage, Hertfordshire, SG1 2NY (UK) |
| Abstract: | A Rh‐catalyzed ortho‐amidation cyclocondensation sequence gave a range of 4‐aminoquinazolines in high yield. The method features a remarkably mild C(sp2)?H activation step and can be exploited to rapidly access compounds with established biological activity. |
| Keywords: | amidation cyclization homogeneous catalysis oxazolines quinazolines |