Drug Delivery Nanocarriers from a Fully Degradable PEG‐Conjugated Polyester with a Reduction‐Responsive Backbone |
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Authors: | Dr Basit Yameen Dr Cristian Vilos Dr Won Il Choi Andrew Whyte Jining Huang Lori Pollit Prof?Dr Omid C Farokhzad |
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Institution: | 1. Laboratory of Nanomedicine and Biomaterials, Department of Anaesthesiology Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115 (USA) http://farokhzad.bwh.harvard.edu/;2. Universidad Andres Bello, Facultad de Medicina, Center for Integrative Medicine and Innovative Science (CIMIS), Echaurren 183, Santiago 8370071 (Chile);3. Univerity of Waterloo, 200 University Avenue West Waterloo, ON, N2L?3G1 (Canada);4. King Abdulaziz University, Jeddah 21589 (Saudi Arabia) |
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Abstract: | The remarkably high intracellular concentration of reducing agents is an excellent endogenous stimulus for designing nanocarriers programmed for intracellular delivery of therapeutic agents. However, despite their excellent biodegradability profiles, aliphatic polyesters that are fully degradable in response to the intracellular reducing environment are rare. Herein, a reduction‐responsive drug delivery nanocarrier derived from a linear polyester bearing disulfide bonds is reported. The reduction‐responsive polyester is synthesized via a convenient polycondensation process. After conjugation of terminal carboxylic acid groups of polyester to polyethylene glycol (PEG), the resulting polymer self‐assembles into nanoparticles that are capable of encapsulating dye and anticancer drug molecules. The reduction‐responsive nanoparticles display a fast payload release rate in response to the intracellular reducing environment, which translates into superior anticancer activity towards PC‐3 cells. |
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Keywords: | bioreducible polyester cancer cytotoxicity drug delivery nanomedicine |
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