PdII‐Catalyzed Intermolecular Amination of Unactivated C(sp3)H Bonds |
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| Authors: | Quan Gou Gang Liu Zi‐Ning Liu Prof. Dr. Jun Qin |
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| Affiliation: | Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, Yunnan, 650091 (P.R. China) |
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| Abstract: | PdII‐catalyzed intermolecular amination of unactivated C(sp3)?H bonds has been successfully developed for the first time. This method provides a new way to achieve the challenging intermolecular amination of unactivated C(sp3)?H bonds, producing a variety of unnatural β2‐amino carboxylic acid analogues. This C(sp3)?H amination protocol is demonstrated with a broad substrate scope, good functional‐group tolerance, and chemoselectivity. It is operated without use of phosphine ligand or external oxidant. |
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| Keywords: | amination C(sp3) H activation cross‐coupling palladium β ‐amino acids |
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