Improved Transversal Relaxivity for Highly Crystalline Nanoparticles of Pure γ‐Fe2O3 Phase |
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| Authors: | Dr Gérald Casterou Vincent Collière Dr Pierre Lecante Dr Yannick Coppel Dr Pierre‐Antoine Eliat Dr Fabienne Gauffre Dr Myrtil L Kahn |
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| Institution: | 1. Laboratoire de Chimie de Coordination, LCC, CNRS, UPR 8241, 205 route de Narbonne, 31077 Toulouse (France);2. Institut des Sciences Chimiques de Rennes ‐ UMR 6226, CNRS‐Université Rennes I, 263 Avenue du General Leclerc, 35042 Rennes Cedex (France);3. d'Elaboration de Matériaux et d'Etudes Structurales, CEMES, CNRS, 29 rue Jeanne Marvig, 31055 Toulouse (France).;4. PRISM ‐ Biosit CNRS UMS 3480, INSERM UMS 018, Rennes (France) |
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| Abstract: | Pure and highly crystalline γ‐Fe2O3 nanocrystals (NCs) are obtained when hydrolysis and oxidation of a FeII organometallic precursor are performed in successive steps. Their synthesis in pure alkylamine leads to NCs of about 6 nm. In aqueous solutions of poly(vinyl)pyrrolidone, such pristine NCs form aggregates of about 150 nm that exhibit a high transversal relaxivity (r2=466 mM ?1 s?1) about four times higher than that of a commercial Feridex magnetic resonance imaging (MRI) contrast agent. Consequently, they provide a significant decrease in the NMR signal at very short echo time (8 ms), which is of paramount importance in clinical practice because of the reduced duration of MRI measurements. |
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| Keywords: | imaging agents iron magnetic properties nanoparticles polymers |
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