Alokicenones A-H,eight tetrahydroanthracenes from the mangrove-derived Streptomyces sp. HN-A101 |
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| Authors: | Dashan Zhang Yongjun Jiang Jiaqi Li Haojian Zhang Wanjing Ding Zhongjun Ma |
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| Institution: | 1. Institute of Marine Biology, Ocean College, Zhejiang University, No. 1 Zheda Rd., Zhoushan 316021, PR China;2. Ocean Academy, Zhejiang University, Zhoushan 316021, PR China |
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| Abstract: | Alokicenones A-H (1–8), eight new tetrahydroanthracenes and one known okicenone (9) were identified from the secondary metabolites of mangrove-derived Streptomyces sp. HN-A101. Their structures were elucidated by HRESIMS and NMR spectroscopic data. The absolute configurations of them were determined by the calculated and experimental ECD curves. Compounds 1–2 and 9 showed moderate cytotoxicity against HCT116 and SW620 cancer cell lines with IC50 values from 0.63 to 7.73?μM. In addition, compounds 1–3 and 7–9 also exhibited inhibitory activities against ROCK2 or BRD4. |
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| Keywords: | Alokicenones A-H Cytotoxicity ROCK2 inhibitory activities BRD4 inhibitory activities |
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