Catalyst- and solvent-free mechanochemical synthesis of isoxazoles from N-hydroxybenzimidoyl chlorides and enamino carbonyl compounds |
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Authors: | Hui Xu Guang-Peng Fan Zi Liu Guan-Wu Wang |
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Institution: | 2. State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, Gansu, 730000, PR China |
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Abstract: | A regioselective, solvent-free and catalyst-free synthesis of isoxazoles has been successfully developed under ball milling conditions. Milling the mixtures of N-hydroxybenzimidoyl chlorides and enamino carbonyl compounds in a ball mill at a frequency of 14.6?Hz for 20–60?min afforded isoxazoles in up to 86% yields. A possible reaction mechanism leading to the formation of the observed isoxazoles is proposed. |
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Keywords: | Mechanochemistry Solvent-free Catalyst-free Isoxazoles Enamino carbonyl compounds |
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