Stability-Indicating Methods for the Determination of Cimetidine Using Derivative and Fourier-Transform Infrared Spectrophotometry |
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| Authors: | Sonia Z El-Khateeb Sawsan M Amer? Sawsan A Abdel Razek Mohamed M Amer |
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| Institution: | Analytical Chemistry Department , Faculty of Pharmacy, Cairo University , Kasr El-Aini, 11562, Cairo, Egypt |
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| Abstract: | Abstract Two different techniques, that is, second (D2) and third (D3) derivative spectrophotometry and fourier transform infrared (FTIR) Spectrophotometry, are investigated for the selective determination of the intact cimetidine in presence of up to 25% and 75% of its degradates, respectively. The procedures determine 2–10 jag ml?1 at 224 nm and 217.5 nm by D2 and D3, respectively, and 1–6 mg per 250 mg in K Br by the FTIR with mean accuracies of 100.0 ± 1.07%, 100.5 ± 0.87% and 100.3 ± 1.16%, respectively. The drug is successfully analysed in its pharmaceutical formulations. |
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