Abstract: | Second‐order rate constants (k2) of the reaction between phenacyl bromide and equimolar mixture of nitrobenzoic acid(s)–triethylamine have been determined in dimethylformamide (DMF)/acetonitrile (ACN)/acetone and aqueous mixtures of these solvents by conductometric method at 30°C. The rates of nitrobenzoic acids are found to be in the order: 4‐NO2 > 3‐NO2 > 3,5‐(NO2)2. Changes in the rate just by the addition of water (1% (v/v)) into organic component is rationalized. Decrease in the values of k2 on increasing water content in organic solvent is explained on the basis of preferential solvation phenomenon. Single and dual regression analysis using the various solvent parameters of aqueous mixtures (ET(30), Z, π*, β, α, and Y) resulted in π* and α as the best parameters to explain solvation of nitrobenzoates. © 2004 Wiley Periodicals, Inc. Int J Chem Kinet 36: 401–409, 2004 |