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| 手性方酰胺基醇钛合物诱导的芳醛的不对称呐醇偶联反应 | |
| 引用本文： | 程青芳,许兴友,许同桃,张祥涛,包静炎. 手性方酰胺基醇钛合物诱导的芳醛的不对称呐醇偶联反应[J]. 有机化学, 2006, 26(11): 1544-1547 |
| 作者姓名： | 程青芳 许兴友 许同桃 张祥涛 包静炎 |
| 作者单位： | 1. 淮海工学院化工系,连云港,222005;南京理工大学材料化学实验室,南京,210094 2. 南京理工大学材料化学实验室,南京,210094 3. 淮海工学院化工系,连云港,222005 |
| 基金项目： | 江苏省科技厅自然科学基金(No．BK2005045)，江苏省教育厅高校自然科学计划(No．05KJD150024)资助项目． |
| 摘 要： | 合成了两个手性方酰胺基醇, 与TiC14(THF)2-Zn形成了手性配合物, 并用来催化芳醛的不对称呐醇偶联反应, 反应取得很高的化学产率和较高的光学收率, 同时考察了芳醛结构和共还原剂对反应的化学产率和光学收率影响. |
| 关 键 词： | 呐醇 手性方酰胺基醇 不对称偶联 芳醛 |
| 收稿时间： | 2006-01-18 |
| 修稿时间： | 2006-05-22 |
Asymmetric Pinacol Coupling of Aromatic Aldehydes Mediated by Chiral Squaric Acid Amidoalcohol-Titanium Complexes |
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| CHENG,Qing-Fang,XU,Xing-You,XU,Tong-Tao,ZHANG,Xiang-Tao,BAO,Jing-Yan. Asymmetric Pinacol Coupling of Aromatic Aldehydes Mediated by Chiral Squaric Acid Amidoalcohol-Titanium Complexes[J]. Chinese Journal of Organic Chemistry, 2006, 26(11): 1544-1547 | |
| Authors: | CHENG Qing-Fang XU Xing-You XU Tong-Tao ZHANG Xiang-Tao BAO Jing-Yan |
| Affiliation: | a Department of Chemical Technology, Huaihai Institute of Technology, Lianyungang 222005;b Laboratory of Materials Chemistry, Nanfing University of Science and Technology, Nanjing 210094 |
| Abstract: | Two enantiopure squaric acid amidoalcohols were synthesized and used for the asymmetric pinacol coupling of aromatic aldehydes with TiC14(THF)2-Zn in excellent yields, high dl-diastereoselectivity and good enantioselectivity. The effect of the structure of aromatic aldehyde and coreductant on the diastereoselectivity and enantioselectivity was also studied. |
| Keywords: | pinacol chiral squaric acid amidoalcohol asymmetric coupling aromatic aldehyde |
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