Microwave-assisted organic synthesis using minivials to optimize and expedite the synthesis of diverse purine libraries |
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| Authors: | Takvorian Amy G Combs Andrew P |
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| Affiliation: | Discovery Chemistry, Experimental Station, Incyte Corporation, Route 141 and Henry Clay Road, Wilmington, DE 19880, USA. |
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| Abstract: | The new Personal Chemistry ultralow-volume (0.2-0.5 mL) minivials are shown to enable small-scale optimization and synthesis of purines at optimal reaction concentrations (0.1-0.4 M), thereby increasing the overall efficiency of this microwave-assisted library synthesis. |
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