低血铅水平与免疫球蛋白和淋巴细胞相关性

目的：探讨低铅水平对IgA、 IgG 、 IgM、 C3、 C4、 B淋巴细胞的影响。方法用石墨炉原子吸收光谱法对39名印刷印染工龄5年以上工人进行血铅测定，另选择距污染源较远且无水系联系的，不受工业污染的，从未接触过重金属的为对照组，分别对两组用免疫比浊法进行（ IgA、IgG、 IgM、 C3和C4）5项测定，流式细胞仪检测血B淋巴细胞水平，全自动生化仪检测白细胞数、总淋巴细胞绝对数和百分比。结果高低铅两组IgA、 IgG 、 IgM、 C3水平比较差异有统计学意义（P＜0.05），白细胞总数、淋巴细胞百分比均低于低铅组（P＜0.05），总淋巴细胞百分比和NK淋巴细胞亚群的绝对数和百分比却低于低铅组（ P＜0.05）。结论高血铅对体液免疫功能有一定的影响。

Association Study of Lead Exposure on Immunoglobulin and B-lymphocyte In 5 Years of Age Printing Workers

Objective To investigate whether lead exposure in su zhou had adverse impact on the level of immunoglobulin in 5 working years printing workers . Methods A total 71 were recruited with 39 （ exposure group ） from Printing workers while 32 from people who stay away from pollution sources （ control group ） .The blood lead level and immunoglobulin were analyzed and compared .Peripheral blood lymphocyte subsets were determined by flow cytometry while full automatic bio -chemical analyzer was used for the percentage and total lymphocytes counts .Results The blood lead level in the exposure group was significantly higher than that of control group （ P〈0.01 ） , The immunoglobulin level （ IgA、IgG、 IgM ） and C3 was significantly lower than that of control group （ P 〈0.05 ） .Similarly , lower percentage of B cells and WBC count were observed in printing workers of suzhou compared with the control.Lower percentage of total lymphocyte and NK cells were observed in printing workers of suzhou compared with the control （ P〈0.05 ） .Conclusion The findings suggest that exposure to lead might have adverse impact on the level of immunoglobulin .