微量元素锌、血清胱抑素 C在糖尿病肾病早期诊断的意义

目的：探讨早期糖尿病肾病患者（ DN）的微量元素锌、血清胱抑素C（ CysC）、血清肌酐（ SCr）和血清尿素（ BUN）水平的变化程度及意义。方法将糖尿病肾病患者分为3组：正常蛋白尿组，微量蛋白尿组，临床蛋白尿组。所有患者和对照组均空腹抽取静脉血检测微量元素锌、血清胱抑素C、血清尿素、血清肌酐。结果正常蛋白尿组、微量蛋白尿组、临床蛋白尿组微量元素锌均明显低于正常对照组，差异有统计学意义（ P＜0.05）。正常蛋白尿组、微量蛋白尿组、临床蛋白尿组血清胱抑素C水平均明显高于正常对照组，差异有统计学意义（ P＜0.05）。微量蛋白尿组、临床蛋白尿组血清肌酐检测值和正常对照组有明显差异，差异有统计学意义（ P＜0.05）。结论检测微量元素锌、血清胱抑素C对糖尿病肾病的早期肾损害有较高的临床价值，可作为早期糖尿病肾病诊断的参考指标。

The Trace Element Zinc,Serum Cystatin C in the Early Diagnosis of Diabetic Nephropathy Significance

Objective Study of early diabetic nephropathy （ DN ） of the trace elements of zinc , serum cystatin C （ CysC） , serum creatinine （ SCr） and serum urea （ BUN） changes and significance of levels . Method The patients with diabetic nephropathy were divided into 3 groups： normal albuminuria group , microalbuminuria group , clinical albuminuria group .All patients and controls were fasting venous blood trace elements zinc, serum cystatin C, serum urea, serum creatinine.Result Normal albuminuria group, microalbuminuria group , clinical albuminuria group of trace elements zinc was significantly lower than that in normal control group , the difference was statistically significant （ P 〈0.05 ） .Normal albuminuria group , microalbuminuria group , clinical albuminuria group serum cystatin C levels were significantly higher than those in normal control group , the difference was statistically significant （ P〈0.05 ） .Serum creatinine microalbuminuria group , clinical albuminuria group detection value and normal control group have obvious difference , the difference was statistically significant （ P 〈0.05 ） . Conclusion Has high clinical value in the detection of trace elements zinc , serum cystatin C in early renal damage in diabetic nephropathy , can be used as a reference index for diagnosis of early diabetic nephropathy .