PipPhos and MorfPhos: privileged monodentate phosphoramidite ligands for rhodium-catalyzed asymmetric hydrogenation |
| |
| Authors: | Bernsmann Heiko van den Berg Michel Hoen Rob Minnaard Adriaan J Mehler Gerlinde Reetz Manfred T De Vries Johannes G Feringa Ben L |
| |
| Affiliation: | Department of Organic and Molecular Inorganic Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands. |
| |
| Abstract: | A library of 20 monodentate phosphoramidite ligands has been prepared and applied in rhodium-catalyzed asymmetric hydrogenation. This resulted in the identification of two ligands, PipPhos and MorfPhos, that afford excellent and in several cases unprecedented enantioselectivities in the hydrogenation of N-acyldehydroamino acid esters, dimethyl itaconate, acyclic N-acylenamides, and cyclic N-acylenamides. In addition, a method for the parallel enantioselectivity determination of eight acylated amines is presented. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
