Efficient TCT-catalyzed synthesis of 1,5-benzodiazepine derivatives under mild conditions |
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| Authors: | Kuo Chun-Wei Wang Chun-Chao Kavala Veerababurao Yao Ching-Fa |
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| Institution: | Department of Chemistry, National Taiwan Normal University, 88, Section 4, Tingchow Road, Taipei 116, Taiwan, ROC. cheyaocf@ntnu.edu.tw. |
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| Abstract: | 2,4,6-Trichloro-1,3,5-triazine (TCT) efficiently catalyzed the condensation reactions between 1,2-diamines and various enolizable ketones to afford 1,5-benzodiazepines in good to excellent yields. Simple and mild reaction conditions, the use of a cheap catalyst and easy workup and isolation are notable features of this method. |
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